Ingredient Consistency—Why It Matters Now More Than Ever
A new study published in Frontiers in Pharmacology has revealed concerning inconsistencies in the alkaloid content of Corydalis yanhusuo (CY) supplements. This traditional herb, widely used for pain and addiction support, showed wildly varying potency across 14 commercially available products. Only 5 matched the natural alkaloid levels; some contained none at all.
These findings underscore a vital truth in the supplement world: ingredient sourcing and verification directly affect both efficacy and safety. For brands and formulators, working with trusted, GMP-compliant manufacturers like OSM is essential to delivering consistent, consumer-safe products.
The Risk of Inconsistency in Herbal Supplementation
Below is a breakdown of the study’s findings, highlighting just how unpredictable poorly sourced CY supplements can be:
| Product Type | Alkaloid Content (mg/g) | Compared to Natural CY |
|---|---|---|
| Natural CY Plant | 12.7 | Baseline |
| Top 5 Commercial Products | 9.5–11.0 | Comparable |
| Remaining Products | 0.0–5.0 | Inconsistent/Undetectable |
For formulators, this raises serious questions around ingredient identity, stability, and labeling compliance. As an organic supplement manufacturer, OSM ensures full-spectrum testing, third-party validation, and batch-level traceability to protect your brand—and your customers.
Why Sourcing from OSM Protects Your Brand & Customers
At Organic Supplement Manufacturing (OSM), our commitment to quality is non-negotiable. Every ingredient we use is rigorously tested for potency, purity, and consistency—backed by certificates of analysis and sourced only from reputable, traceable farms and extractors.
- ✅ GMP-compliant production processes
- ✅ Ingredient transparency & sourcing verification
- ✅ Batch-specific lab testing & documentation
- ✅ In-house R&D for maximum bioavailability
- ✅ Turnkey support for white label or custom formulations
Don’t leave product performance—or your customers’ trust—to chance. Partner with OSM to ensure what’s on your label is what’s in the bottle, every single time.
Source: Frontiers in Pharmacology (2025), Vanderbilt University Study
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