OSM Industry Intel • Summer 2026 The Brain’s Immune Cells Get Stuck in Attack Mode. The Fix Is Not More Antioxidant. It Is the Right Amount. A new Frontiers in Nutrition review reframes neuroprotection around microglial immune state and a dose-response curve that is shaped like an upside-down U. The implication for formulators is uncomfortable […]
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OSM Industry Intel • Spring 2026 The NIH Just Tested 8 Longevity Compounds. All 8 Failed. The Reason Should Change How You Formulate. The gold-standard longevity screen posted a clean sweep of nulls in 2026, including a compound that passed the same test three years ago. The dose gap between those two results is the […]
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OSM Industry Intel • Spring 2026 Brain Fog Might Be a Fuel Delivery Problem. Here Is the Metabolic Workaround Brands Should Watch. A January 2026 review lays out how the aging or insulin-resistant brain slowly loses its ability to burn glucose, and how alternative fuels like ketones may sidestep the broken machinery entirely. Here is […]
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OSM Industry Intel • Spring 2026 Science Just Found the Cellular “Toxic Waste Leak” Behind Inflammaging. Here Is the Supplement Angle. A 2025 review pulls together a striking discovery: aging immune cells lose the ability to take out their own cellular trash, then leak mitochondrial DNA that the body mistakes for a viral invasion. The […]
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OSM Industry Intel • Spring 2026 A Trace Mineral Just Became the Most Interesting Story in Brain Aging. And One Specific Form Steals the Show. A landmark 2025 study in Nature found that one mineral, and only one, was selectively depleted in the brains of people with cognitive decline: lithium. The plot twist involves amyloid […]
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OSM Industry Intel • 2026 The Apigenin Story Just Got More Interesting: A Common Flavonoid That Raises Cellular NAD+ A peer-reviewed study shows the plant flavonoid apigenin inhibits CD38, the enzyme that quietly burns through your NAD+ supply. For brands building longevity and metabolic SKUs, this is a mechanism worth understanding. NAD+ has been having […]
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OSM Industry Intel • Spring 2026 Your Customers’ Mouthwash Might Be Raising Their Blood Pressure. That Is a Supplement Opportunity. A review in the Journal of Dental Research lays out how bacteria on the back of the tongue convert dietary nitrate into the raw material for nitric oxide, and how killing those bacteria removes up […]
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OSM Industry Intel • Spring 2026 Vitamin D Might Be a Circadian Clock Ingredient, Not Just a Bone Health One A new review in the International Journal of Molecular Sciences lays out the case that vitamin D helps regulate the body’s biological clock, with implications for sleep, mood, and metabolic health. Here is what it […]
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Low-Dose Melatonin and the Climacteric: What a New Shift-Worker Trial Means for Brands Building Women’s Wellness Supplements A fresh randomized controlled trial in nurses gives supplement brands a useful data point for the women’s wellness shelf. Here’s what formulators, product managers, and contract manufacturing partners should actually take away. If you spend any time in […]
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Common Supplement Brand Errors That Turn Into Costly Fixes Most contract manufacturing problems don’t start as “big problems.” They start as small shortcuts that only show up later as failed stability, inconsistent potency, messy labels, or customer complaints. The brands that win in 2026 are the ones that treat manufacturing like a system: formulation, documentation, […]
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