The NAD+ Supplement Hype—Is It Backed by Science?
In the world of anti-aging supplements, NAD+ precursors have become one of the most heavily marketed solutions. These compounds are designed to boost levels of nicotinamide adenine dinucleotide (NAD+), a molecule involved in cellular energy and mitochondrial function. As we age, NAD+ levels naturally decline, and many companies argue that restoring them can slow aging and preserve muscle health.
However, a recent study from the University of Copenhagen casts serious doubt on those claims. Even when researchers reduced NAD+ levels by a dramatic 85% in mice, the animals maintained normal muscle function and metabolism throughout their lifespan. This suggests that the body may be far more resilient to NAD+ decline than supplement companies want you to believe.
What the Study Actually Found
The research, published in Cell Metabolism, used genetically modified mice with severely depleted NAD+ in their skeletal muscles. Scientists expected to see signs of aging or weakness, but instead found no loss of strength, endurance, or metabolic health—even after a lifetime of low NAD levels.
| Key Metric | NAD-Depleted Mice | Control Mice |
|---|---|---|
| Muscle Strength | Normal | Normal |
| Exercise Performance | Normal with Minor Stress | Normal |
| Mitochondrial Health | Unchanged | Unchanged |
These findings challenge the core narrative that age-related NAD+ declines must be corrected with supplements in order to maintain health. According to the researchers, even dramatic NAD+ reductions don’t trigger muscle aging or frailty.
Our Take—Science First, Always
At Organic Supplement Manufacturing, we don’t chase trends—we follow data. While NAD+ boosters may sound promising in theory, the science just isn’t there yet to support their everyday use. We focus instead on developing organic supplements with clinically studied ingredients that support real outcomes: better mobility, reduced inflammation, and improved overall wellness.
We encourage our partners and customers to dig deeper, ask questions, and choose products based on what’s proven—not just popular. Learn more at organicmfg.com.
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