Vitamin C Reactivates Skin’s Youth Genes
Recent findings from the Tokyo Metropolitan Institute for Geriatrics and Gerontology reveal that Vitamin C does more than support immune health—it plays a direct role in skin rejuvenation. As we age, the outermost layer of skin, known as the epidermis, naturally thins. This weakens the skin’s protective barrier and reduces its ability to heal and regenerate.
The study, published in the Journal of Investigative Dermatology, found that Vitamin C stimulates the expression of genes responsible for skin cell growth and renewal. It accomplishes this through a process called DNA demethylation, effectively turning “youth genes” back on in aging skin. These insights open the door for more effective anti-aging and skin-repair strategies using topical or ingestible Vitamin C formulations.
Mechanisms of Action: DNA Demethylation and Cell Proliferation
Using laboratory-grown models of human skin, researchers exposed epidermal cells to Vitamin C concentrations that mirror levels naturally present in the human body. After 7 to 14 days, the treated skin showed significant thickening of the inner epidermal layer, with a higher rate of cell division marked by Ki-67-positive cells.
This rejuvenation was attributed to Vitamin C’s ability to sustain the function of TET enzymes, which are responsible for removing methyl groups from DNA. This demethylation allows previously inactive genes—specifically those tied to skin growth—to become active again. Researchers observed over 10,000 hypomethylated regions and a substantial boost in 12 key genes involved in skin cell proliferation.
By converting inactive DNA into a readable state, Vitamin C enables the skin to regenerate more effectively, especially in older adults experiencing age-related thinning or damage.
Harnessing the Power of Vitamin C in Custom Formulations
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